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1.
J Dairy Sci ; 98(3): 1983-90, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25557892

RESUMO

Forty-eight Holstein cows (32 multiparous and 16 primiparous) in mid to late lactation averaging 219±71 days in milk and 30.5±6.6 kg/d of 3.5% fat-corrected milk were used in a 56-d completely randomized design experiment to evaluate condensed corn distillers solubles (CCDS) inclusion in high-fiber total mixed rations (TMR). Inclusion rates evaluated were 0, 6.6, 13.2, and 19.8% CCDS as a percentage of dry matter (DM). Distiller solubles substituted for soybean meal, corn grain, and whole cottonseed such that diets were similar in protein (16.6%) and fat (4.50%). Water was added to 0, 6.6, and 13.2% CCDS treatments so that final TMR DM concentrations (47.8%) were similar across diets. The forage portion of the diet was kept constant at 19.6% annual ryegrass hay and 26.0% sorghum baleage. Diet in vitro true digestibility tended to increase as CCDS addition increased, but neutral detergent fiber digestibility trended lower in CCDS diets. Percent P (0.39, 0.55, 0.69, and 0.73%) and S (0.32, 0.35, 0.39, and 0.42%) in TMR increased as CCDS concentration increased. Milk yield (23.5, 24.7, 25.5, and 24.8 kg/d of 3.5% fat-corrected milk) was similar for control and CCDS diets. Milk fat (3.88, 3.73, 3.78, and 3.68%), protein (3.28, 3.27, 3.31, and 3.31%), and lactose (4.61, 4.66, 4.69, and 4.77) percentages were similar across diets. Milk urea nitrogen (16.60, 15.58, 15.43, and 14.75 mg/dL) declined with increasing CCDS addition. Animal activity, body weight, body condition scores, and locomotion scores were not influenced by CCDS. Day 28 poststudy locomotion scores were similar across diets. Ruminal acetate concentrations did not differ among diets, but propionate and butyrate concentrations were elevated in rumen fluid of cows receiving 19.6% CCDS. Although rumen fluid pH values were similar (6.5, 6.4, 6.3, and 6.2), the two highest CCDS diets exhibited depressed acetate:propionate ratios relative to controls. The results from this study indicate that CCDS may be included in high-fiber TMR for lactating dairy cows at up to nearly 20% of diet DM; however, caution is recommended because high CCDS P concentrations may create Ca:P imbalances and excess P may be introduced into the environment.


Assuntos
Fenômenos Fisiológicos da Nutrição Animal , Bovinos/fisiologia , Dieta/veterinária , Suplementos Nutricionais , Lactação/fisiologia , Zea mays/metabolismo , Ração Animal/análise , Animais , Suplementos Nutricionais/análise , Relação Dose-Resposta a Droga , Feminino , Leite/metabolismo , Distribuição Aleatória , Zea mays/química
3.
Asian-Australas J Anim Sci ; 27(10): 1436-42, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25178295

RESUMO

Preservation of forage crops as silage offers opportunity to avoid the high risk of rain-damaged hay in the humid south-central USA. Recent developments with baled silage or baleage make silage a less expensive option than typical chopped silage. Silage has been important in the region primarily for dairy production, but baleage has become an option for the more extensive beef cattle industry in the region. Silage samples submitted to the Louisiana State University Agricultural Center Forage Quality Lab from 2006 through 2013 were assessed for dry matter (DM) and forage nutritive characteristics of chopped silage and baleage of the different forage types from commercial farms primarily in Louisiana and Mississippi. Of the 1,308 silage samples submitted, 1,065 were annual ryegrass (AR) with small grains (SG), the warm-season annual (WA) grasses, sorghums and pearl millet, and the warm-season perennial (WP) grasses, bermudagrass and bahiagrass, providing the remaining samples. Concentration of DM was used to indicate an effective ensiling opportunity, and AR silage was more frequently within the target DM range than was the WA forage group. The AR samples also indicated a high-quality forage with average crude protein (CP) of 130 g/kg and total digestible nutrient (TDN) near 600 g/kg. The cooler winter weather at harvest apparently complicated harvest of SG silage with chopped SG silage lower in both CP and TDN (104 and 553 g/kg, respectively) than either AR silage or baleage of SG (137 and 624 g/kg for CP and TDN, respectively). The hot, humid summer weather along with large stems and large forage quantities of the WA grasses and the inherently higher fiber concentration of WP grasses at harvest stage indicate that preservation of these forage types as silage will be challenging, although successful commercial silage samples of each forage type and preservation approach were included among samples of silages produced in the region.

4.
Asian-Australas J Anim Sci ; 27(9): 1276-84, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25178371

RESUMO

In southeastern regions of the US, herbage systems are primarily based on grazing or hay feeding with low nutritive value warm-season perennial grasses. Nutritious herbage such as annual ryegrass (Lolium multiflorum Lam.) may be more suitable for preserving as baleage for winter feeding even with more intensive production inputs. Emerging in-line wrapped baleage storage systems featuring rapid wrapping and low polyethylene film requirements need to be tested for consistency of storing nutritive value of a range of annual ryegrass herbage. A ryegrass storage trial was conducted with 24-h wilted 'Marshall' annual ryegrass harvested at booting, heading and anthesis stages using three replicated in-line wrapped tubes containing ten round bales per tube. After a six-month storage period, nutritive value changes and fermentation end products differed significantly by harvest stage but not by bale location. Although wilted annual ryegrass exhibited a restricted fermentation across harvest stages characterized by high pH and low fermentation end product concentrations, butyric acid concentrations were less than 1 g/kg dry matter, and lactic acid was the major organic acid in the bales. Mold coverage and bale aroma did not differ substantially with harvest stage or bale location. Booting and heading stage-harvested ryegrass baleage were superior in nutritive value to anthesis stage-harvested herbage. Based on the investigated nutritive value and fermentation characteristics, individual bale location within in-line tubes did not significantly affect preservation quality of ryegrass round bale silages.

5.
J Hand Surg Eur Vol ; 37(4): 336-41, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21965181

RESUMO

The trabecular microstructure of normal lunates and lunates with Kienböck's disease was investigated using micro-computed tomography (micro-CT). Five lunates with advanced Kienböck's disease were obtained during lunate excision and scaphocapitate fusion, and five control lunates were from embalmed cadavers. Microstructural morphometric parameters were measured using micro-CT images. Trabeculations of lunates with Kienböck's disease were 2.67 times denser and 1.84 times thicker than those of normal lunates. Furthermore, bone surface areas were 1.43 times greater and bone volume 2.67 times greater, and structural model indices were significantly lower in lunates with Kienböck's disease. The study estimated that high mechanical stress would be applied to lunates with Kienböck's disease, and suggests that new bone formation and collapse may play important roles in the microstructural changes in the lunate with advanced Kienböck's disease.


Assuntos
Osso Semilunar/diagnóstico por imagem , Osteonecrose/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto , Ossos do Carpo/diagnóstico por imagem , Feminino , Humanos , Imageamento Tridimensional , Masculino , Microrradiografia , Pessoa de Meia-Idade
6.
J Dairy Sci ; 94(5): 2500-7, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21524542

RESUMO

A study was conducted to determine the effect of conserving bahiagrass as outdoor-stored hay (OSH), barn-stored hay (BSH), or baleage (BAL) on storage losses and lactation performance by Holstein cows. For baleage production, bahiagrass forage was cut and allowed to dry for 20 h in windrows, baled (1.2 × 1.4 m), and individually wrapped with white stretch film. Forage cut on the same day was dried to hay stage, baled (1.2 × 1.6 m round bales), and stored either outdoors (OSH) or in an enclosed hay barn (BSH). Bales were core sampled and weighed at harvest and again following a 6-mo storage period. At the end of the storage period, 30 multiparous mid-lactation Holstein cows [39.2 ± 5.6 kg of 3.5% fat-corrected milk and 142 ± 27 d in milk (DIM)] were stratified according to milk yield and DIM and randomly assigned to 1 of the 3 forage conservation treatments. Cows were trained to Calan feeding gates and were offered a common partial mixed ration in a 10-d covariate period followed by a 42-d treatment feeding period. Forage dry matter losses were highest for OSH, but were similar between BSH and baleage. Conservation method had little effect on poststorage crude protein levels, but acid detergent fiber and neutral detergent fiber concentrations were higher in OSH than in either BSH or BAL, which resulted in a 12.8% depression in net energy for OSH compared with the other treatments. Dry matter intake (20.5 vs. 22.1 kg/d) and milk yield (28.2 vs. 30.2 kg/d) tended to be lower for OSH than for BSH. Lactation performance was similar between BSH and BAL: 29.6 versus 28.7 kg/d of fat-corrected milk, respectively. No differences in milk composition, feed efficiency, body weight, or body condition score change related to conservation system were observed. In this study, dry matter losses and lactation performance from bahiagrass conserved as baleage were similar to that of similar forage stored indoors as hay, whereas hay stored outside resulted in less satisfactory forage quality.


Assuntos
Ração Animal/análise , Bovinos/fisiologia , Indústria de Laticínios/métodos , Lactação/fisiologia , Paspalum/metabolismo , Fenômenos Fisiológicos da Nutrição Animal , Animais , Bovinos/metabolismo , Gorduras na Dieta/análise , Ingestão de Alimentos/fisiologia , Feminino , Leite/química , Leite/metabolismo , Valor Nutritivo
7.
Phys Rev Lett ; 102(3): 037402, 2009 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-19257393

RESUMO

Using predesigned trains of femtosecond optical pulses, we have selectively excited coherent phonons of the radial breathing mode of specific-chirality single-walled carbon nanotubes within an ensemble sample. By analyzing the initial phase of the phonon oscillations, we prove that the tube diameter initially increases in response to ultrafast photoexcitation. Furthermore, from excitation profiles, we demonstrate that an excitonic absorption peak of carbon nanotubes periodically oscillates as a function of time when the tube diameter undergoes coherent radial breathing mode oscillations.

8.
Nanotechnology ; 19(50): 505202, 2008 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-19942763

RESUMO

Among the conjugate polymers, poly(3,4-ethylenedioxythiophene):poly (styrenesulfonate) (PEDOT:PSS) has been paid a great deal of attention for various application fields. The absorption intensity of the whole UV-visible range increases linearly, as the concentration of PEDOT:PSS increases. When a small amount of TiO(2) nanoparticles are dispersed in the PEDOT:PSS solution, the absorption in the visible range normally increases, but the UV range absorption (TiO(2) absorption area) is greatly depressed as the concentration of PEDOT:PSS increases. Various weight ratios of TiO(2) nanoparticles in PEDOT:PSS were prepared. The TiO(2)/PEDOT:PSS solution was spin-coated onto the Al electrode and thermally treated to remove water molecules and densify the film. These thermal processes generated nanocracks and nanoholes on the surface of the TiO(2)/PEDOT:PSS film. As the heating temperature increased, wider and longer nanocracks were generated. These nanocracks and nanoholes can be removed by subsequent coating and heating processes. Schottky diodes were fabricated using four different concentrations of TiO(2)-PEDOT:PSS solution. The forward current increased nearly two orders of magnitude by doping approximately 1% of TiO(2) nanoparticles in PEDOT:PSS. Increasing the TiO(2) nanoparticles in the PEDOT:PSS matrix, the forward current was continuously enhanced. The enhancement of forward current is nearly four orders of magnitude with respect to the pristine PEDOT:PSS Schottky diode. The possible conduction mechanisms were examined by using various plotting and curve-fitting methods including a space-charge-limited conduction mechanism [Ln(J) versus Ln(V)], Schottky emission mechanism [Ln(J) versus E(1/2)], and Poole-Frenkel emission mechanism [Ln(J/V) versus E(1/2)]. The plot of Ln(J) versus Ln(V) shows a linear relationship, implying that the major conduction mechanism is SCLC. As the concentration of TiO(2) increased, the conduction mechanism slightly detracted from the ideal SCLC mechanism.

9.
Oncogene ; 25(9): 1434-6, 2006 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-16247455

RESUMO

A missense somatic mutation in JAK2 gene (JAK2 V617F) has recently been reported in chronic myeloproliferative disorders, including polycythemia vera, essential thrombocythemia and myelofibrosis with myeloid metaplasia, strongly suggesting its role in the pathogenesis of myeloid disorders. As activation of JAK2 signaling is occurred in other malignancies as well, we have analysed 558 tissues from common human cancers, including colon, breast and lung carcinomas, and 143 acute adulthood leukemias by polymerase chain reaction -- single strand conformation polymorphism analysis. We found three JAK2 mutations in the 113 acute myelogenous leukemias (AMLs) (2.7%), but none in other cancers. The mutations consisted of two V617F mutations and one K607N mutation. None of the AML patients with the JAK2 V617F mutation had a history of previous hematologic disorders. This is the first report on the JAK2 gene mutation in AML, and the data indicated that the JAK2 gene mutation may not only contribute to the development of chronic myeloid disorders, but also to some AMLs.


Assuntos
Leucemia Mieloide Aguda/genética , Proteínas Tirosina Quinases/genética , Proteínas Proto-Oncogênicas/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/genética , Carcinoma/genética , Carcinoma Ductal de Mama/genética , Carcinoma Pulmonar de Células não Pequenas/genética , Neoplasias Colorretais/genética , Análise Mutacional de DNA , Feminino , Humanos , Janus Quinase 2 , Neoplasias Pulmonares/genética , Masculino , Pessoa de Meia-Idade , Mutação de Sentido Incorreto , Reação em Cadeia da Polimerase , Polimorfismo Conformacional de Fita Simples , Proteínas Tirosina Quinases/fisiologia , Proteínas Proto-Oncogênicas/fisiologia
10.
Korean J Intern Med ; 13(2): 143-6, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9735673

RESUMO

CMV infection may occur anywhere in the gastrointestinal tract. Among the small intestine, ileum is the most common site of CMV disease and infection of jejunum is a rare one in patients with CMV gastroenteritis. Although rare, the reason why the recognition of this diagnosis is important is that it cause the lethal hemorrhage and perforation of gastrointestinal tract when its diagnosis and treatment was delayed. Rapid diagnosis are able to using the immunohistochemical stain in shell vial culture of infected specimen or peripheral neutrophils preparation in viremic patients within 8 to 36 hours. The treatment of choice is antiviral agent or surgical resection. We experienced a case of CMV disease of jejunum in patient with non-Hodgkin's lymphoma who showed severe ulceration in jejunum and massive intestinal hemorrhage, and he survived after successful treatment with segmental resection of jejunum and intravenous ganciclovir.


Assuntos
Infecções por Citomegalovirus/complicações , Hemorragia Gastrointestinal/etiologia , Doenças do Jejuno/complicações , Linfoma não Hodgkin/complicações , Infecções Oportunistas/complicações , Adulto , Antivirais/uso terapêutico , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/tratamento farmacológico , Intervalo Livre de Doença , Enterite/complicações , Enterite/cirurgia , Enterite/virologia , Ganciclovir/uso terapêutico , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/terapia , Humanos , Doenças do Jejuno/cirurgia , Doenças do Jejuno/virologia , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/tratamento farmacológico , Masculino , Infecções Oportunistas/diagnóstico , Infecções Oportunistas/tratamento farmacológico
11.
Life Sci ; 62(19): 1809-16, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9585112

RESUMO

Our previous studies on alpha1-adrenoceptor signaling suggested that G alpha(h) family is a signal mediator in different species. To elucidate the species-specificity of G alpha(h) family in molecular mass, we used the solubilized membranes from mouse heart and the ternary complex preparations containing alpha1-agonist/receptor/G-protein. Binding of [35S]GTPgammaS and the intensity of the [alpha-32P]GTP photoaffinity labeled protein resulting from activation of the alpha1-adrenoceptor were significantly attenuated by the antagonist, phentolamine. The molecular mass of the specific GTP-binding protein was approximately 72-kDa; homologous with G alpha(h) (transglutaminase II) family. Furthermore, immunological cross-reactivity of ternary complex from mouse heart and purified G alpha(h) from rat, guinea pig, and bovine using anti-G alpha(h7) antibody showed that their molecular masses were distinctly different and approximately 72-kDa G alpha(h) from mouse heart was the lowest molecular mass. Consistent with these observations, in co-immunoprecipitation and co-immunoadsorption of the alpha1-adrenoceptor in the ternary complex preparation by anti-G alpha(h7) antibody, the G alpha(h) family protein tightly coupled to alpha1-adrenoceptor. These results demonstrate the species-specificity of G alpha(h) family in molecular mass, especially the lowest molecular mass in mouse.


Assuntos
GTP Fosfo-Hidrolases/isolamento & purificação , Miocárdio/metabolismo , Receptores Adrenérgicos alfa 1/metabolismo , Transglutaminases/isolamento & purificação , Animais , Bovinos , GTP Fosfo-Hidrolases/imunologia , GTP Fosfo-Hidrolases/metabolismo , Proteínas de Ligação ao GTP/imunologia , Proteínas de Ligação ao GTP/metabolismo , Cobaias , Camundongos , Camundongos Endogâmicos ICR , Proteína 2 Glutamina gama-Glutamiltransferase , Ratos , Receptores Adrenérgicos alfa 1/imunologia , Especificidade da Espécie , Transglutaminases/imunologia , Transglutaminases/metabolismo
12.
Biochem J ; 331 ( Pt 1): 283-9, 1998 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-9512491

RESUMO

Although the oxytocin receptor modulates intracellular Ca2+ ion levels in myometrium, the identities of signal molecules have not been clearly clarified. Our previous studies on oxytocin receptor signalling demonstrated that 80 kDa Ghalpha is a signal mediator [Baek, Kwon, Lee, Kim, Muralidhar and Im (1996) Biochem. J. 315, 739-744]. To elucidate the effector in the oxytocin receptor signalling pathway, we evaluated the oxytocin-mediated activation of phospholipase C (PLC) by using solubilized membranes from human myometrium and a three-component preparation containing the oxytocin receptor-Ghalpha-PLC-delta1 complex. PLC-delta1 activity in the three-component preparation, as well as PLC activity in solubilized membranes, was increased by oxytocin in the presence of Ca2+ and activated Ghalpha (GTP-bound Ghalpha). Furthermore the stimulated PLC-delta1 activity resulting from activation of Ghalpha via the oxytocin receptor was significantly attenuated by the selective oxytocin antagonist desGly-NH2d(CH2)5[Tyr(Me)2,Thr4]ornithine vasotocin or GDP. Consistent with these observations, co-immunoprecipitation and co-immunoadsorption of PLC-delta1 in the three-component preparation by anti-Gh7alpha antibody resulted in the PLC-delta1 being tightly coupled to activated Ghalpha on stimulation of the oxytocin receptor. These results indicate that PLC-delta1 is the effector for Ghalpha-mediated oxytocin receptor signalling.


Assuntos
Membrana Celular/metabolismo , Isoenzimas/metabolismo , Miométrio/metabolismo , Ocitocina/metabolismo , Receptores de Ocitocina/metabolismo , Transdução de Sinais , Fosfolipases Tipo C/metabolismo , Cálcio/metabolismo , Feminino , Humanos , Ocitocina/farmacologia , Fosfolipase C delta , Transdução de Sinais/efeitos dos fármacos
13.
Exp Mol Med ; 30(2): 81-6, 1998 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-9873827

RESUMO

We previously reported an identification of a 77-kDa GTP-binding protein that co-purified with the alpha 1-adrenoceptor following ternary complex formation. In the present paper, we report on the purification and characterization of this GTP-binding protein (termed G alpha h5) isolated from pig heart membranes. After solubilization of pig heart membranes with NaCl, G alpha h5 was purified by sequential chromatographies using DEAE-Cellulose, Q-Sepharose, and GTP-agarose columns. The protein displayed high-affinity GTP gamma S binding which is Mg(2+)-dependent and saturable. The relative order of affinity of nucleotide binding by G alpha h5 was GTP > GDP > ITP >> ATP > or = adenyl-5'-yl imidodiphosphate, which was similar to that observed for other heterotrimeric G-proteins involved in receptor signaling. Moreover, the G alpha h5 demonstrated transglutaminase (TGase) activity that was blocked either by EGTA or GTP gamma S. In support of these observations, the G alpha h5 was recognized by a specific antibody to G alpha h7 or TGase II, indicating a homology with G alpha h (TGase II) family. These results demonstrate that 77-kDa G alpha h5 from pig heart is an alpha 1-adrenoceptor-coupled G alpha h (TGase II) family which has species-specificity in molecular mass.


Assuntos
Proteínas de Ligação ao GTP/isolamento & purificação , Proteínas de Ligação ao GTP/metabolismo , Miocárdio/química , Animais , Sítios de Ligação , Ligação Competitiva , Reações Cruzadas , Proteínas de Ligação ao GTP/imunologia , Guanosina 5'-O-(3-Tiotrifosfato)/metabolismo , Peso Molecular , Receptores Adrenérgicos alfa 1/metabolismo , Suínos , Transglutaminases/metabolismo
14.
J Korean Med Sci ; 9(5): 382-7, 1994 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7702786

RESUMO

Graft-versus-host disease (GVHD) is a life threatening complication that may occur following allogenic bone marrow transplantation (BMT) in the patients with aplastic anemia, leukemia or genetic immunodeficiency. It has been known that GVHD occurs approximately 70% of recipients of BMT in western countries but no definite incidence has been reported in Korea. In our St. Mary's Hospital, GVHD occurs in about 30% of BMT recipients. Histopathologically the acute phase skin shows diffuse lymphocytic infiltrates in the upper dermis with extensive exocytosis. Scattered throughout the epidermis are many degenerated keratinocytes, which are often associated with one or more satellite lymphocytes (satellite cell necrosis). In the chronic phase, acanthosis, eosinophilic keratinocytes resembling colloid bodies and mononuclear cell infiltrates in the upper dermis are noted. We reviewed 5 cases of acute GVHD and 6 cases of chronic GVHD. All patients received allogenic BMT from Jan. 1, 1992 to July 1, 1993. Ten patients were male and one was female. The mean age was 34 (20-70). The pathologic diagnosis was 3 cases of CML, 2 of ALL, 2 of AML (FAB M2), 2 of aplastic anemia, 1 of CLL and 1 of AML (FAB M5). The interval from BMT to GVHD varied from 14 days to 4 years (median 220 days). The skin and GI tract were involved in all eleven cases. Ten cases were histologically proven by skin biopsies, and two cases by salivary gland and colonic biopsies, respectively. The histological findings of the skin, salivary gland and colonic biopsieds were described. Immunohistochemical stain of the skin was done using CD4, CD8, HLA DR and Leu 7 antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Doença Enxerto-Hospedeiro/patologia , Adulto , Idoso , Biópsia , Antígenos CD4/análise , Antígenos CD8/análise , Feminino , Doença Enxerto-Hospedeiro/imunologia , Antígenos HLA-DR/análise , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade
15.
Gan To Kagaku Ryoho ; 19(8 Suppl): 1188-92, 1992 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-1514832

RESUMO

Bone marrow transplantation from an HLA-identical sibling is increasingly used as a curative therapy for patients with hemopoietic stem cell disorders including acute leukemia, chronic myelogenous leukemia and severe aplastic anemia. Between March 1983 and March 1991, we performed 86 cases of allogeneic bone marrow transplantation (BMT) for the patients with hemopoietic stem cell disorders: 25 acute myelogenous leukemia (AML); 15 acute lymphoblastic leukemia (ALL); 20 chronic myelogenous leukemia (CML); and 26 severe aplastic anemia (SAA). Ten out of 25 AML are in disease free survival (DFS). The causes of death were recurrence of leukemia (12), acute GVHD (3), sepsis (1) and veno-occlusive disease (1). Nine of 15 ALL are in unmaintained remission. Thirteen out of 20 CML are in DFS. Among 26 SAA, 21 are enjoying DFS, but 1 died of engraftment failure, 3 of graft rejection followed by cytomegalovirus (1) and aspergillus pneumonia (1). Comparing the survival between standard [less than or equal to CR1: 9/14 (64%)] and high risk [greater than or equal to CR1: 1/11 (9%)] AML, our data suggest that preparative regimen for high risk AML was not potent enough to eradicate the minimal residual disease in advanced AML. Although our cases are limited and the follow-up period is short, our result of ALL [overall: CCR (60%), standard risk (adult less than or equal to CR1, children less than or equal to CR2; 8/11 (73%) and high risk; 1/4 (25%)] and CML [overall: 65%, CP; 9/10 (90%), AP; 4/6 (67%), BP; 0/4 (0%)] are optimistic. It is of our interest that the incidence of death related with IP (1/33: 3%) and with AGVHD 94/33: 12%) were much less than that of other's observation but the explanation for this still remains to be clear.


Assuntos
Anemia Aplástica/cirurgia , Transplante de Medula Óssea , Leucemia/cirurgia , Doença Aguda , Adolescente , Adulto , Anemia Aplástica/terapia , Transplante de Medula Óssea/mortalidade , Terapia Combinada , Feminino , Doença Enxerto-Hospedeiro/etiologia , Humanos , Imunoterapia , Leucemia/terapia , Masculino , Pessoa de Meia-Idade , Taxa de Sobrevida , Transplante Homólogo
16.
Kanho Hakhoe Chi ; 21(2): 150-67, 1991 Aug.
Artigo em Coreano | MEDLINE | ID: mdl-1921098

RESUMO

The intent of this longitudinal descriptive correlational study is to investigate the change of the mother-infant interactions over the periods of one month, three months and six months of the infant's age. This study is also intended to explore the interrelationships among three major factors--the perception of pregnancy, the mother-infant interaction and the maternal attitude. The samples participated are 36 pairs of mother and infant from two university hospitals in Seoul. A data collection was made, from October in 1988 to September in 1989, for each subject at five periods of time; prenatal period (after 36 weeks in pregnancy), postpartum two or three days, one month, three months and six months of infant's age. The research tools used in this investigation are Mother-Infant Play Interaction Scale (MIPIS), Prenatal Self-Evaluation Questionnaire and Cohler's Maternal Attitude Scale. Some of the findings are as follows; 1. There is a significant increase in the mother-infant interaction from one month to three months and six months of infant's age. The highest score of the mother-infant interaction during three periods is at the time of three months. 2. The primipara's mother-infant interaction is not affected by the demographic characteristics, such as age, education and vocation of mother, types of delivery, or sex of infant. 3. Among seven categories of the perception of pregnancy, the most positively perceived categories by primiparas are acceptance of pregnancy and identification of a motherhood role; whereas the negative ones are preparation for labor, concern for well-being of self and baby, and fear of pain, helplessness and loss of control in order of negativity. 4. There is no significant relationship between the perception of pregnancy and the mother-infant interactions. 5. There is no significant change in the maternal attitude over the period of one month, three months, and six months of infant's age. 6. There is no significant relationship between the maternal attitude and the mother-infant interactions. 7. The significant relationships are found between the perception of pregnancy and maternal attitude, especially in the categories of concern for well-being of self and baby, acceptance of pregnancy, identification of a motherhood role, fear of pain, helplessness and loss of control, and relationship with husband. In conclusion, it is confirmed that primipara's mother-infant interactions change over time period, and that perception of pregnancy and the maternal attitude do not affect the mother-infant interactions despite a significant relationship between those two variables.(ABSTRACT TRUNCATED AT 400 WORDS)


Assuntos
Relações Mãe-Filho , Fatores Etários , Feminino , Humanos , Recém-Nascido , Estudos Longitudinais , Masculino , Paridade , Gravidez , Fatores Sexuais
17.
Kanho Hakhoe Chi ; 21(1): 79-88, 1991 Apr.
Artigo em Coreano | MEDLINE | ID: mdl-1812312

RESUMO

The study was conducted to examine Mother-Infant interaction and Maternal identity in two groups, that is, premature infant and its mother and full-term infant and its mother. For this purpose, the data were collected from 24 sample groups (12 for premature dyads and the remaining 12 for full-term dyads) by using observation method and questionnaires during July 20 through September 30, 1987. The results are summarized as follows: 1. In terms of Mother-Infant Interaction, full-term dyads considerably stood out compared to that of premature dyads (u = 21, p less than 0.01). 2. In terms of Maternal Identity, though full-term dyads showed somewhat high results, there was not a significant difference between two groups. 3. There was not a significant correlation between Mother-Infant Interaction and Maternal Identity.


Assuntos
Recém-Nascido , Recém-Nascido Prematuro , Relações Mãe-Filho , Mães , Identificação Social , Feminino , Humanos , Inquéritos e Questionários
18.
Kanho Hakhoe Chi ; 21(1): 89-116, 1991 Apr.
Artigo em Coreano | MEDLINE | ID: mdl-1812313

RESUMO

The purpose of this study was to describe mother-infant interacting behavior patterns related to newborn infant feeding and to explore the mother's cultural belief about their infant. The data collection was conducted by observation and interview. Twenty-five mothers and their newborn infants who were normally delivered and were also planned to breastfeed were comprised as the subjects of this study. All subjects were interviewed and observed individually at 1 to 5 days after the delivery at the hospital, mid-wife's clinic, Maternal Child Health Center and their home throughout the country from remote area to big city. The observation data were recorded with symbolic letter on a recording sheet newly developed as a result of preliminary study. The interview data were tape recorded and then recorded in narrative form. Mother-infant interaction behaviors in early-feeding period were analyzed based on 19 analytic sub-categories and their composing elements. Unit of analysis were mother, infant and mother-infant dyad. 8 analytic categories draw from the data. Each were preparation, instrument, interaction inducing, evaluation referred to mother's behavior, preparation, instrument, interaction inducing referred to infant's behavior and synchronic behaviors referred to mother-infant dyad. Frequencies of behavior items based on the categories were converted to percent. The result showed that in mother's preparation behavior, the breast condition of Korean mother can be an affecting factor for mother-infant interaction during feeding, and vocalization behavior was observed most frequently in interaction inducing behavior while the least frequent behavior observed was contacting. Subcultural characteristics of mother-infant interaction behaviors were analyzed for their relationships between groups of mothers who have lived in remote area vs urban area, and who were multipara vs primipara. Using a chi-square test, there were statistically significant relationships in the activity of psychological readiness in preparation behavior and the movement of extremities for the position of instrumental behavior in both groups. However, interaction inducing behaviors were not related with statistical significance in any set of groups. Accomplishment of marriage, bonding and emotional mediation of family members were the categories related to mother's cultural belief about the infant in aspect of functional values. Infant at birth is considered little more than a biological organism without social capabilities. Although the newborn infant is still be attached to his mother, he makes his mother extend her territoriality. The mother's interacting behavior toward her infant based on those beliefs appeared task oriented, separative behavioral series.(ABSTRACT TRUNCATED AT 400 WORDS)


Assuntos
Aleitamento Materno , Relações Mãe-Filho , Cultura , Humanos , Recém-Nascido , Entrevistas como Assunto , Coreia (Geográfico) , Pais/educação , Valores Sociais
20.
Taehan Kanho ; 26(2): 33-6, 1987 Jun 30.
Artigo em Coreano | MEDLINE | ID: mdl-3649492
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